Endocrine Abstracts

Multiple Endocrine Neoplasia Type 1 (MEN1) and the von Hippel Lindau syndrome (VHL) are hereditary disease with an autosomal dominant inheritance. Among a wide variety of manifestations, both syndromes predispose patients to pancreatic neuro-endocrine neoplasms (PanNENs). Screening for presymptomatic diagnosis of PanNENs enables timely intervention with the intention to prevent metastasized disease and premature death. MEN1 and VHL lead to different manifestations and there ar...

Introduction: The variable tumor behavior in patients with gastro-entero-pancreatic neuroendocrine tumors (GEPNETs) is challenging. Current general biomarkers are insufficient to predict the disease course. An emerging biomarker is the NETest, a blood-based gene signature that can predict disease status based on the expression of genes involved in tumor biology. While promising, the accuracy and reproducibility of results in daily practice during years of follow up has never b...

Background: Pancreatic Neuroendocrine Tumors (PanNETs) are highly prevalent in Multiple Endocrine Neoplasia type 1 (MEN1) and one of the main causes of mortality. Conventional imaging is the mainstay of PanNET screening/surveillance in MEN1. This study aims to assess the diagnostic accuracy of conventional pancreatic imaging studies and to determine the added value of pancreatic fine needle aspirations (FNA) for the diagnosis of MEN1-related PanNETs.Meth...